A randomized, controlled study of peginterferon lambda-1a/ribavirin ± daclatasvir for hepatitis C virus genotype 2 or 3
Identifieur interne : 002440 ( Main/Exploration ); précédent : 002439; suivant : 002441A randomized, controlled study of peginterferon lambda-1a/ribavirin ± daclatasvir for hepatitis C virus genotype 2 or 3
Auteurs : Graham R. Foster [Royaume-Uni] ; Kazuaki Chayama [Japon] ; Wan-Long Chuang [Taïwan] ; Hugo Fainboim [Argentine] ; Martti Farkkila [Finlande] ; Adrian Gadano [Argentine] ; Giovanni B. Gaeta [Italie] ; Christophe Hézode [France] ; Yukiko Inada [Japon] ; Jeong Heo [Corée du Sud] ; Hiromitsu Kumada [Japon] ; Sheng-Nan Lu [Taïwan] ; Patrick Marcellin [France] ; Christophe Moreno [Belgique] ; Stuart K. Roberts [Australie] ; Simone I. Strasser ; Alexander J. Thompson [Australie] ; Joji Toyota [Japon] ; Seung Woon Paik [Corée du Sud] ; John M. Vierling [États-Unis] ; Anna L. Zignego [Italie] ; David Cohen [États-Unis] ; Fiona Mcphee [États-Unis] ; Megan Wind-Rotolo [États-Unis] ; Subasree Srinivasan [États-Unis] ; Matthew Hruska [États-Unis] ; Heather Myler [États-Unis] ; Simon D. Portsmouth [États-Unis]Source :
- SpringerPlus [ 2193-1801 ] ; 2016.
Abstract
Peginterferon Lambda was being developed as an alternative to alfa interferon for the treatment of chronic hepatitis C virus (HCV) infection. We compared peginterferon Lambda-1a plus ribavirin (Lambda/RBV) and Lambda/RBV plus daclatasvir (DCV; pangenotypic NS5A inhibitor) with peginterferon alfa-2a plus RBV (alfa/RBV) in treatment-naive patients with HCV genotype 2 or 3 infection.
In this multicenter, double-blind, phase 3 randomized controlled trial, patients were assigned 2:2:1 to receive 24 weeks of Lambda/RBV, 12 weeks of Lambda/RBV + DCV, or 24 weeks of alfa/RBV. The primary outcome measure was sustained virologic response at post-treatment Week 12 (SVR12).
Overall, 874 patients were treated: Lambda/RBV,
The 12-week regimen of Lambda/RBV + DCV was superior to peginterferon alfa/RBV in the combined population of treatment-naive patients with genotype 2 or 3 infection, with an improved tolerability and safety profile compared with alfa/RBV.
The online version of this article (doi:10.1186/s40064-016-2920-z) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40064-016-2920-z
PubMed: 27588258
PubMed Central: 4990525
Affiliations:
- Argentine, Australie, Belgique, Corée du Sud, Finlande, France, Italie, Japon, Royaume-Uni, Taïwan, États-Unis
- Angleterre, Connecticut, Grand Londres, New Jersey, Région capitale de Séoul, Région de Kantō, Texas, Victoria (État), Vienne (Autriche), Île-de-France
- Bruxelles, Créteil, Londres, Melbourne, Séoul, Tokyo, Vienne (Autriche)
- Université de Londres, Université de Melbourne, Université libre de Bruxelles
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Foster</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Hepatology, Queen Mary University of London, 4 Newark Street, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Hepatology, Queen Mary University of London, 4 Newark Street, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Chayama, Kazuaki" sort="Chayama, Kazuaki" uniqKey="Chayama K" first="Kazuaki" last="Chayama">Kazuaki Chayama</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Gastroenterology and Nutrition, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Nutrition, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Chuang, Wan Long" sort="Chuang, Wan Long" uniqKey="Chuang W" first="Wan-Long" last="Chuang">Wan-Long Chuang</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Fainboim, Hugo" sort="Fainboim, Hugo" uniqKey="Fainboim H" first="Hugo" last="Fainboim">Hugo Fainboim</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Liver Unit, Hospital F. J. Muñiz, Uspallata 2272, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Liver Unit, Hospital F. J. 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Gaeta</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Internal and Specialistic Medicine, Viral Hepatitis Unit, Second University of Naples, Via Pansini 5 Bld.3, 08131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Internal and Specialistic Medicine, Viral Hepatitis Unit, Second University of Naples, Via Pansini 5 Bld.3, 08131 Naples</wicri:regionArea><wicri:noRegion>08131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Hepatology, Henri Mondor Hospital, AP-HP, INSERM U955, University Paris-Est, 51 av du Maréchal de Lattre de Tassigny, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hepatology, Henri Mondor Hospital, AP-HP, INSERM U955, University Paris-Est, 51 av du Maréchal de Lattre de Tassigny, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Inada, Yukiko" sort="Inada, Yukiko" uniqKey="Inada Y" first="Yukiko" last="Inada">Yukiko Inada</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Center for Digestive and Liver Diseases, Miyazaki Medical Center Hospital, 2-16 Takamtsu-cho, Miyazaki-shi, Miyazaki, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Center for Digestive and Liver Diseases, Miyazaki Medical Center Hospital, 2-16 Takamtsu-cho, Miyazaki-shi, Miyazaki</wicri:regionArea><wicri:noRegion>Miyazaki</wicri:noRegion></affiliation></author><author><name sortKey="Heo, Jeong" sort="Heo, Jeong" uniqKey="Heo J" first="Jeong" last="Heo">Jeong Heo</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Department of Internal Medicine, Pusan National University and Medical Research Institute, College of Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-gu, Pusan, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Pusan National University and Medical Research Institute, College of Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-gu, Pusan</wicri:regionArea><wicri:noRegion>Pusan</wicri:noRegion></affiliation></author><author><name sortKey="Kumada, Hiromitsu" sort="Kumada, Hiromitsu" uniqKey="Kumada H" first="Hiromitsu" last="Kumada">Hiromitsu Kumada</name><affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Lu, Sheng Nan" sort="Lu, Sheng Nan" uniqKey="Lu S" first="Sheng-Nan" last="Lu">Sheng-Nan Lu</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Section of Hepatology, Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Taoei Road, Niaosung District, Kaohsiung, 833 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Section of Hepatology, Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Taoei Road, Niaosung District, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation 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Brussels</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K." last="Roberts">Stuart K. Roberts</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Gastroenterology, Alfred Hospital, 99 Commercial Road, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gastroenterology, Alfred Hospital, 99 Commercial Road, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff16">Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Strasser, Simone I" sort="Strasser, Simone I" uniqKey="Strasser S" first="Simone I." last="Strasser">Simone I. Strasser</name><affiliation><nlm:aff id="Aff17">AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Sydney, NSW 20150 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 20150 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J." last="Thompson">Alexander J. Thompson</name><affiliation wicri:level="4"><nlm:aff id="Aff18">Department of Gastroenterology, St. Vincent’s Hospital and the University of Melbourne, SVHM Level 4 Daly Wing, 35 Victoria Pde, PO Box 29000, Fitzroy, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Gastroenterology, St. Vincent’s Hospital and the University of Melbourne, SVHM Level 4 Daly Wing, 35 Victoria Pde, PO Box 29000, Fitzroy</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Toyota, Joji" sort="Toyota, Joji" uniqKey="Toyota J" first="Joji" last="Toyota">Joji Toyota</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Department of Hepatology, Sapporo Kosei General Hospital, Kita 3 Higashi 8-5, Chuo-ku, Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hepatology, Sapporo Kosei General Hospital, Kita 3 Higashi 8-5, Chuo-ku, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Paik, Seung Woon" sort="Paik, Seung Woon" uniqKey="Paik S" first="Seung Woon" last="Paik">Seung Woon Paik</name><affiliation wicri:level="3"><nlm:aff id="Aff20">Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Vierling, John M" sort="Vierling, John M" uniqKey="Vierling J" first="John M." last="Vierling">John M. 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Zignego</name><affiliation wicri:level="1"><nlm:aff id="Aff22">Department of Experimental and Clinical Medicine, MASVE Center, Universita Di Firenze, Largo Brambilia, 3, 50134 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, MASVE Center, Universita Di Firenze, Largo Brambilia, 3, 50134 Florence</wicri:regionArea><wicri:noRegion>50134 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, David" sort="Cohen, David" uniqKey="Cohen D" first="David" last="Cohen">David Cohen</name><affiliation wicri:level="2"><nlm:aff id="Aff23">Bristol-Myers Squibb Global Biometric Sciences, 5 Research Parkway, Wallingford, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Bristol-Myers Squibb Global Biometric Sciences, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><affiliation wicri:level="2"><nlm:aff id="Aff24">Discovery Virology, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Discovery Virology, Bristol-Myers Squibb, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation></author><author><name sortKey="Wind Rotolo, Megan" sort="Wind Rotolo, Megan" uniqKey="Wind Rotolo M" first="Megan" last="Wind-Rotolo">Megan Wind-Rotolo</name><affiliation wicri:level="2"><nlm:aff id="Aff25">Exploratory Clinical and Translational Research, Bristol-Myers Squibb Company, Princeton, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Exploratory Clinical and Translational Research, Bristol-Myers Squibb Company, Princeton</wicri:cityArea></affiliation></author><author><name sortKey="Srinivasan, Subasree" sort="Srinivasan, Subasree" uniqKey="Srinivasan S" first="Subasree" last="Srinivasan">Subasree Srinivasan</name><affiliation wicri:level="2"><nlm:aff id="Aff26">Global Clinical Research, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Global Clinical Research, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation></author><author><name sortKey="Hruska, Matthew" sort="Hruska, Matthew" uniqKey="Hruska M" first="Matthew" last="Hruska">Matthew Hruska</name><affiliation wicri:level="2"><nlm:aff id="Aff27">Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb Company, Hopewell, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb Company, Hopewell</wicri:cityArea></affiliation></author><author><name sortKey="Myler, Heather" sort="Myler, Heather" uniqKey="Myler H" first="Heather" last="Myler">Heather Myler</name><affiliation wicri:level="2"><nlm:aff id="Aff28">Analytical and Bioanalytical Development, Bristol Myers Squibb Company, Princeton, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Analytical and Bioanalytical Development, Bristol Myers Squibb Company, Princeton</wicri:cityArea></affiliation></author><author><name sortKey="Portsmouth, Simon D" sort="Portsmouth, Simon D" uniqKey="Portsmouth S" first="Simon D." last="Portsmouth">Simon D. 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Foster</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Hepatology, Queen Mary University of London, 4 Newark Street, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Hepatology, Queen Mary University of London, 4 Newark Street, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Chayama, Kazuaki" sort="Chayama, Kazuaki" uniqKey="Chayama K" first="Kazuaki" last="Chayama">Kazuaki Chayama</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Gastroenterology and Nutrition, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Nutrition, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Chuang, Wan Long" sort="Chuang, Wan Long" uniqKey="Chuang W" first="Wan-Long" last="Chuang">Wan-Long Chuang</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Fainboim, Hugo" sort="Fainboim, Hugo" uniqKey="Fainboim H" first="Hugo" last="Fainboim">Hugo Fainboim</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Liver Unit, Hospital F. J. Muñiz, Uspallata 2272, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Liver Unit, Hospital F. J. Muñiz, Uspallata 2272, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Farkkila, Martti" sort="Farkkila, Martti" uniqKey="Farkkila M" first="Martti" last="Farkkila">Martti Farkkila</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Helsinki University and Clinic of Gastroenterology, University of Helsinki, Haartmaninkatu 4, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University and Clinic of Gastroenterology, University of Helsinki, Haartmaninkatu 4, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Gadano, Adrian" sort="Gadano, Adrian" uniqKey="Gadano A" first="Adrian" last="Gadano">Adrian Gadano</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Gaeta, Giovanni B" sort="Gaeta, Giovanni B" uniqKey="Gaeta G" first="Giovanni B." last="Gaeta">Giovanni B. Gaeta</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Internal and Specialistic Medicine, Viral Hepatitis Unit, Second University of Naples, Via Pansini 5 Bld.3, 08131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Internal and Specialistic Medicine, Viral Hepatitis Unit, Second University of Naples, Via Pansini 5 Bld.3, 08131 Naples</wicri:regionArea><wicri:noRegion>08131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Hepatology, Henri Mondor Hospital, AP-HP, INSERM U955, University Paris-Est, 51 av du Maréchal de Lattre de Tassigny, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hepatology, Henri Mondor Hospital, AP-HP, INSERM U955, University Paris-Est, 51 av du Maréchal de Lattre de Tassigny, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Inada, Yukiko" sort="Inada, Yukiko" uniqKey="Inada Y" first="Yukiko" last="Inada">Yukiko Inada</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Center for Digestive and Liver Diseases, Miyazaki Medical Center Hospital, 2-16 Takamtsu-cho, Miyazaki-shi, Miyazaki, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Center for Digestive and Liver Diseases, Miyazaki Medical Center Hospital, 2-16 Takamtsu-cho, Miyazaki-shi, Miyazaki</wicri:regionArea><wicri:noRegion>Miyazaki</wicri:noRegion></affiliation></author><author><name sortKey="Heo, Jeong" sort="Heo, Jeong" uniqKey="Heo J" first="Jeong" last="Heo">Jeong Heo</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Department of Internal Medicine, Pusan National University and Medical Research Institute, College of Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-gu, Pusan, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Pusan National University and Medical Research Institute, College of Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-gu, Pusan</wicri:regionArea><wicri:noRegion>Pusan</wicri:noRegion></affiliation></author><author><name sortKey="Kumada, Hiromitsu" sort="Kumada, Hiromitsu" uniqKey="Kumada H" first="Hiromitsu" last="Kumada">Hiromitsu Kumada</name><affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Lu, Sheng Nan" sort="Lu, Sheng Nan" uniqKey="Lu S" first="Sheng-Nan" last="Lu">Sheng-Nan Lu</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Section of Hepatology, Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Taoei Road, Niaosung District, Kaohsiung, 833 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Section of Hepatology, Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Taoei Road, Niaosung District, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Hepatology, Hôpital Beaujon, 100 Bd du Général Leclerc, 92110 Clichy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hepatology, Hôpital Beaujon, 100 Bd du Général Leclerc, 92110 Clichy</wicri:regionArea><wicri:noRegion>92110 Clichy</wicri:noRegion><wicri:noRegion>92110 Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Christophe" sort="Moreno, Christophe" uniqKey="Moreno C" first="Christophe" last="Moreno">Christophe Moreno</name><affiliation wicri:level="4"><nlm:aff id="Aff14">Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K." last="Roberts">Stuart K. Roberts</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Gastroenterology, Alfred Hospital, 99 Commercial Road, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gastroenterology, Alfred Hospital, 99 Commercial Road, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff16">Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Strasser, Simone I" sort="Strasser, Simone I" uniqKey="Strasser S" first="Simone I." last="Strasser">Simone I. Strasser</name><affiliation><nlm:aff id="Aff17">AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Sydney, NSW 20150 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 20150 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J." last="Thompson">Alexander J. Thompson</name><affiliation wicri:level="4"><nlm:aff id="Aff18">Department of Gastroenterology, St. Vincent’s Hospital and the University of Melbourne, SVHM Level 4 Daly Wing, 35 Victoria Pde, PO Box 29000, Fitzroy, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Gastroenterology, St. Vincent’s Hospital and the University of Melbourne, SVHM Level 4 Daly Wing, 35 Victoria Pde, PO Box 29000, Fitzroy</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Toyota, Joji" sort="Toyota, Joji" uniqKey="Toyota J" first="Joji" last="Toyota">Joji Toyota</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Department of Hepatology, Sapporo Kosei General Hospital, Kita 3 Higashi 8-5, Chuo-ku, Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hepatology, Sapporo Kosei General Hospital, Kita 3 Higashi 8-5, Chuo-ku, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Paik, Seung Woon" sort="Paik, Seung Woon" uniqKey="Paik S" first="Seung Woon" last="Paik">Seung Woon Paik</name><affiliation wicri:level="3"><nlm:aff id="Aff20">Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Vierling, John M" sort="Vierling, John M" uniqKey="Vierling J" first="John M." last="Vierling">John M. Vierling</name><affiliation wicri:level="2"><nlm:aff id="Aff21">Baylor Liver Health, Baylor College of Medicine, 6620 Main Street, Suite 1425, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor Liver Health, Baylor College of Medicine, 6620 Main Street, Suite 1425, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Zignego, Anna L" sort="Zignego, Anna L" uniqKey="Zignego A" first="Anna L." last="Zignego">Anna L. Zignego</name><affiliation wicri:level="1"><nlm:aff id="Aff22">Department of Experimental and Clinical Medicine, MASVE Center, Universita Di Firenze, Largo Brambilia, 3, 50134 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, MASVE Center, Universita Di Firenze, Largo Brambilia, 3, 50134 Florence</wicri:regionArea><wicri:noRegion>50134 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, David" sort="Cohen, David" uniqKey="Cohen D" first="David" last="Cohen">David Cohen</name><affiliation wicri:level="2"><nlm:aff id="Aff23">Bristol-Myers Squibb Global Biometric Sciences, 5 Research Parkway, Wallingford, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Bristol-Myers Squibb Global Biometric Sciences, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><affiliation wicri:level="2"><nlm:aff id="Aff24">Discovery Virology, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Discovery Virology, Bristol-Myers Squibb, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation></author><author><name sortKey="Wind Rotolo, Megan" sort="Wind Rotolo, Megan" uniqKey="Wind Rotolo M" first="Megan" last="Wind-Rotolo">Megan Wind-Rotolo</name><affiliation wicri:level="2"><nlm:aff id="Aff25">Exploratory Clinical and Translational Research, Bristol-Myers Squibb Company, Princeton, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Exploratory Clinical and Translational Research, Bristol-Myers Squibb Company, Princeton</wicri:cityArea></affiliation></author><author><name sortKey="Srinivasan, Subasree" sort="Srinivasan, Subasree" uniqKey="Srinivasan S" first="Subasree" last="Srinivasan">Subasree Srinivasan</name><affiliation wicri:level="2"><nlm:aff id="Aff26">Global Clinical Research, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Global Clinical Research, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation></author><author><name sortKey="Hruska, Matthew" sort="Hruska, Matthew" uniqKey="Hruska M" first="Matthew" last="Hruska">Matthew Hruska</name><affiliation wicri:level="2"><nlm:aff id="Aff27">Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb Company, Hopewell, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb Company, Hopewell</wicri:cityArea></affiliation></author><author><name sortKey="Myler, Heather" sort="Myler, Heather" uniqKey="Myler H" first="Heather" last="Myler">Heather Myler</name><affiliation wicri:level="2"><nlm:aff id="Aff28">Analytical and Bioanalytical Development, Bristol Myers Squibb Company, Princeton, NJ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Analytical and Bioanalytical Development, Bristol Myers Squibb Company, Princeton</wicri:cityArea></affiliation></author><author><name sortKey="Portsmouth, Simon D" sort="Portsmouth, Simon D" uniqKey="Portsmouth S" first="Simon D." last="Portsmouth">Simon D. Portsmouth</name><affiliation wicri:level="2"><nlm:aff id="Aff26">Global Clinical Research, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Global Clinical Research, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff29">Shionogi Inc., 300 Campus Drive, Florham Park, NJ 07932 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Shionogi Inc., 300 Campus Drive, Florham Park</wicri:cityArea></affiliation></author></analytic><series><title level="j">SpringerPlus</title><idno type="eISSN">2193-1801</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and purpose</title><p>Peginterferon Lambda was being developed as an alternative to alfa interferon for the treatment of chronic hepatitis C virus (HCV) infection. We compared peginterferon Lambda-1a plus ribavirin (Lambda/RBV) and Lambda/RBV plus daclatasvir (DCV; pangenotypic NS5A inhibitor) with peginterferon alfa-2a plus RBV (alfa/RBV) in treatment-naive patients with HCV genotype 2 or 3 infection.</p></sec><sec><title>Methods</title><p>In this multicenter, double-blind, phase 3 randomized controlled trial, patients were assigned 2:2:1 to receive 24 weeks of Lambda/RBV, 12 weeks of Lambda/RBV + DCV, or 24 weeks of alfa/RBV. The primary outcome measure was sustained virologic response at post-treatment Week 12 (SVR12).</p></sec><sec><title>Results</title><p>Overall, 874 patients were treated: Lambda/RBV, <italic>n</italic> = 353; Lambda/RBV + DCV, <italic>n</italic> = 349; alfa/RBV, <italic>n</italic> = 172. Patients were 65 % white and 33 % Asian, 57 % male, with a mean age of 47 years; 52 % were infected with genotype 2 (6 % cirrhotic) and 48 % with genotype 3 (9 % cirrhotic). In the Lambda/RBV + DCV group, 83 % (95 % confidence interval [CI] 78.5, 86.5) achieved SVR12 (90 % genotype 2, 75 % genotype 3) whereas SVR12 was achieved by 68 % (95 % CI 63.1, 72.9) with Lambda/RBV (72 % genotype 2, 64 % genotype 3) and 73 % (95 % CI 66.6, 79.9) with peginterferon alfa/RBV (74 % genotype 2, 73 % genotype 3). Lambda/RBV + DCV was associated with lower incidences of flu-like symptoms, hematological abnormalities, and discontinuations due to adverse events compared with alfa/RBV.</p></sec><sec><title>Conclusion</title><p>The 12-week regimen of Lambda/RBV + DCV was superior to peginterferon alfa/RBV in the combined population of treatment-naive patients with genotype 2 or 3 infection, with an improved tolerability and safety profile compared with alfa/RBV.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s40064-016-2920-z) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Andersen, H" uniqKey="Andersen H">H Andersen</name></author><author><name sortKey="Meyer, J" uniqKey="Meyer J">J Meyer</name></author><author><name sortKey="Freeman, J" uniqKey="Freeman J">J 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uniqKey="Barbaro G">G Barbaro</name></author><author><name sortKey="Romano, M" uniqKey="Romano M">M Romano</name></author><author><name sortKey="Barlattani, A" uniqKey="Barlattani A">A Barlattani</name></author><author><name sortKey="Mazzoni, E" uniqKey="Mazzoni E">E Mazzoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muir, Aj" uniqKey="Muir A">AJ Muir</name></author><author><name sortKey="Arora, S" uniqKey="Arora S">S Arora</name></author><author><name sortKey="Everson, G" uniqKey="Everson G">G Everson</name></author><author><name sortKey="Flisiak, R" uniqKey="Flisiak R">R Flisiak</name></author><author><name sortKey="George, J" uniqKey="George J">J George</name></author><author><name sortKey="Ghalib, R" uniqKey="Ghalib R">R Ghalib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Dr" uniqKey="Nelson D">DR Nelson</name></author><author><name sortKey="Cooper, Jn" uniqKey="Cooper J">JN Cooper</name></author><author><name sortKey="Lalezari, Jp" uniqKey="Lalezari J">JP Lalezari</name></author><author><name sortKey="Lawitz, E" uniqKey="Lawitz E">E Lawitz</name></author><author><name sortKey="Pockros, Pj" uniqKey="Pockros P">PJ Pockros</name></author><author><name sortKey="Gitlin, N" uniqKey="Gitlin N">N Gitlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poordad, F" uniqKey="Poordad F">F Poordad</name></author><author><name sortKey="Schiff, Er" uniqKey="Schiff E">ER Schiff</name></author><author><name sortKey="Vierling, Jm" uniqKey="Vierling J">JM Vierling</name></author><author><name sortKey="Landis, C" uniqKey="Landis C">C Landis</name></author><author><name sortKey="Fontana, Rj" uniqKey="Fontana R">RJ Fontana</name></author><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Probst, A" uniqKey="Probst A">A Probst</name></author><author><name sortKey="Dang, T" uniqKey="Dang T">T Dang</name></author><author><name sortKey="Bochud, M" uniqKey="Bochud M">M Bochud</name></author><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author><author><name sortKey="Negro, F" uniqKey="Negro F">F Negro</name></author><author><name sortKey="Bochud, Py" uniqKey="Bochud P">PY Bochud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Kr" uniqKey="Reddy K">KR Reddy</name></author><author><name sortKey="Pol, S" uniqKey="Pol S">S Pol</name></author><author><name sortKey="Thuluvath, Pj" uniqKey="Thuluvath P">PJ Thuluvath</name></author><author><name sortKey="Dumada, H" uniqKey="Dumada H">H Dumada</name></author><author><name sortKey="Toyota, J" uniqKey="Toyota J">J Toyota</name></author><author><name sortKey="Chayama, K" uniqKey="Chayama K">K Chayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Db" uniqKey="Smith D">DB Smith</name></author><author><name sortKey="Bukh, J" uniqKey="Bukh J">J Bukh</name></author><author><name sortKey="Kuiken, C" uniqKey="Kuiken C">C Kuiken</name></author><author><name sortKey="Muerhoff, As" uniqKey="Muerhoff A">AS Muerhoff</name></author><author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name></author><author><name sortKey="Stapleton, Jt" uniqKey="Stapleton J">JT Stapleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulkowski, Ms" uniqKey="Sulkowski M">MS Sulkowski</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Hunyady, B" uniqKey="Hunyady B">B Hunyady</name></author><author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name></author><author><name sortKey="Ogurtsov, P" uniqKey="Ogurtsov P">P Ogurtsov</name></author><author><name sortKey="Peck Radosavljevic, M" uniqKey="Peck Radosavljevic M">M Peck-Radosavljevic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulkowski, Ms" uniqKey="Sulkowski M">MS Sulkowski</name></author><author><name sortKey="Gardiner, Df" uniqKey="Gardiner D">DF Gardiner</name></author><author><name sortKey="Rodriguez Torres, M" uniqKey="Rodriguez Torres M">M Rodriguez-Torres</name></author><author><name sortKey="Reddy, Kr" uniqKey="Reddy K">KR Reddy</name></author><author><name sortKey="Hassanein, T" uniqKey="Hassanein T">T Hassanein</name></author><author><name sortKey="Jacobson, I" uniqKey="Jacobson I">I Jacobson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vierling, Jm" uniqKey="Vierling J">JM Vierling</name></author><author><name sortKey="Lataillade, M" uniqKey="Lataillade M">M Lataillade</name></author><author><name sortKey="Gane, E" uniqKey="Gane E">E Gane</name></author><author><name sortKey="Lueth, S" uniqKey="Lueth S">S Lueth</name></author><author><name sortKey="Serfaty, L" uniqKey="Serfaty L">L Serfaty</name></author><author><name sortKey="Taliani, G" uniqKey="Taliani G">G Taliani</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wyles, Dl" uniqKey="Wyles D">DL Wyles</name></author><author><name sortKey="Ruane, Pj" uniqKey="Ruane P">PJ Ruane</name></author><author><name sortKey="Sulkowski, Ms" uniqKey="Sulkowski M">MS Sulkowski</name></author><author><name sortKey="Dieterich, D" uniqKey="Dieterich D">D Dieterich</name></author><author><name sortKey="Luetkemeyer, A" uniqKey="Luetkemeyer A">A Luetkemeyer</name></author><author><name sortKey="Morgan, Tr" uniqKey="Morgan T">TR Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeuzem, S" uniqKey="Zeuzem S">S Zeuzem</name></author><author><name sortKey="Hultcrantz, R" uniqKey="Hultcrantz R">R Hultcrantz</name></author><author><name sortKey="Bourliere, M" uniqKey="Bourliere M">M Bourliere</name></author><author><name sortKey="Goeser, T" uniqKey="Goeser T">T Goeser</name></author><author><name sortKey="Marcellin, P" uniqKey="Marcellin P">P Marcellin</name></author><author><name sortKey="Sanchez Tapias, J" uniqKey="Sanchez Tapias J">J Sanchez-Tapias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeuzem, S" uniqKey="Zeuzem S">S Zeuzem</name></author><author><name sortKey="Dusheiko, Gm" uniqKey="Dusheiko G">GM Dusheiko</name></author><author><name sortKey="Salupere, R" uniqKey="Salupere R">R Salupere</name></author><author><name sortKey="Mangia, A" uniqKey="Mangia A">A Mangia</name></author><author><name sortKey="Flisiak, R" uniqKey="Flisiak R">R Flisiak</name></author><author><name sortKey="Hyland, Rh" uniqKey="Hyland R">RH Hyland</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Argentine</li><li>Australie</li><li>Belgique</li><li>Corée du Sud</li><li>Finlande</li><li>France</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Connecticut</li><li>Grand Londres</li><li>New Jersey</li><li>Région capitale de Séoul</li><li>Région de Kantō</li><li>Texas</li><li>Victoria (État)</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Créteil</li><li>Londres</li><li>Melbourne</li><li>Séoul</li><li>Tokyo</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de Londres</li><li>Université de Melbourne</li><li>Université libre de Bruxelles</li></orgName></list><tree><noCountry><name sortKey="Strasser, Simone I" sort="Strasser, Simone I" uniqKey="Strasser S" first="Simone I." last="Strasser">Simone I. Strasser</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Foster, Graham R" sort="Foster, Graham R" uniqKey="Foster G" first="Graham R." last="Foster">Graham R. Foster</name></region></country><country name="Japon"><noRegion><name sortKey="Chayama, Kazuaki" sort="Chayama, Kazuaki" uniqKey="Chayama K" first="Kazuaki" last="Chayama">Kazuaki Chayama</name></noRegion><name sortKey="Inada, Yukiko" sort="Inada, Yukiko" uniqKey="Inada Y" first="Yukiko" last="Inada">Yukiko Inada</name><name sortKey="Kumada, Hiromitsu" sort="Kumada, Hiromitsu" uniqKey="Kumada H" first="Hiromitsu" last="Kumada">Hiromitsu Kumada</name><name sortKey="Toyota, Joji" sort="Toyota, Joji" uniqKey="Toyota J" first="Joji" last="Toyota">Joji Toyota</name></country><country name="Taïwan"><noRegion><name sortKey="Chuang, Wan Long" sort="Chuang, Wan Long" uniqKey="Chuang W" first="Wan-Long" last="Chuang">Wan-Long Chuang</name></noRegion><name sortKey="Lu, Sheng Nan" sort="Lu, Sheng Nan" uniqKey="Lu S" first="Sheng-Nan" last="Lu">Sheng-Nan Lu</name></country><country name="Argentine"><noRegion><name sortKey="Fainboim, Hugo" sort="Fainboim, Hugo" uniqKey="Fainboim H" first="Hugo" last="Fainboim">Hugo Fainboim</name></noRegion><name sortKey="Gadano, Adrian" sort="Gadano, Adrian" uniqKey="Gadano A" first="Adrian" last="Gadano">Adrian Gadano</name></country><country name="Finlande"><noRegion><name sortKey="Farkkila, Martti" sort="Farkkila, Martti" uniqKey="Farkkila M" first="Martti" last="Farkkila">Martti Farkkila</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Gaeta, Giovanni B" sort="Gaeta, Giovanni B" uniqKey="Gaeta G" first="Giovanni B." last="Gaeta">Giovanni B. Gaeta</name></noRegion><name sortKey="Zignego, Anna L" sort="Zignego, Anna L" uniqKey="Zignego A" first="Anna L." last="Zignego">Anna L. Zignego</name></country><country name="France"><region name="Île-de-France"><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name></region><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name></country><country name="Corée du Sud"><noRegion><name sortKey="Heo, Jeong" sort="Heo, Jeong" uniqKey="Heo J" first="Jeong" last="Heo">Jeong Heo</name></noRegion><name sortKey="Paik, Seung Woon" sort="Paik, Seung Woon" uniqKey="Paik S" first="Seung Woon" last="Paik">Seung Woon Paik</name></country><country name="Belgique"><region name="Vienne (Autriche)"><name sortKey="Moreno, Christophe" sort="Moreno, Christophe" uniqKey="Moreno C" first="Christophe" last="Moreno">Christophe Moreno</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K." last="Roberts">Stuart K. Roberts</name></region><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K." last="Roberts">Stuart K. Roberts</name><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J." last="Thompson">Alexander J. Thompson</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Vierling, John M" sort="Vierling, John M" uniqKey="Vierling J" first="John M." last="Vierling">John M. Vierling</name></region><name sortKey="Cohen, David" sort="Cohen, David" uniqKey="Cohen D" first="David" last="Cohen">David Cohen</name><name sortKey="Hruska, Matthew" sort="Hruska, Matthew" uniqKey="Hruska M" first="Matthew" last="Hruska">Matthew Hruska</name><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><name sortKey="Myler, Heather" sort="Myler, Heather" uniqKey="Myler H" first="Heather" last="Myler">Heather Myler</name><name sortKey="Portsmouth, Simon D" sort="Portsmouth, Simon D" uniqKey="Portsmouth S" first="Simon D." last="Portsmouth">Simon D. Portsmouth</name><name sortKey="Portsmouth, Simon D" sort="Portsmouth, Simon D" uniqKey="Portsmouth S" first="Simon D." last="Portsmouth">Simon D. Portsmouth</name><name sortKey="Srinivasan, Subasree" sort="Srinivasan, Subasree" uniqKey="Srinivasan S" first="Subasree" last="Srinivasan">Subasree Srinivasan</name><name sortKey="Wind Rotolo, Megan" sort="Wind Rotolo, Megan" uniqKey="Wind Rotolo M" first="Megan" last="Wind-Rotolo">Megan Wind-Rotolo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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